the roles of t helper 1, t helper 17 and regulatory t cells in the pathogenesis of sarcoidosis
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abstract
sarcoidosis is a systemic granulomatous disorder of unidentified etiology, with a heterogeneous clinical presentation. it is characterized by a reduced delayed-type hypersensitivity to tuberculin and common antigens. the balance between th1, th17 and regulatory t(treg) cells controls t-cell proliferation and activation.the th17/treg ratio in the peripheral blood and bronchoalveolar lavage fluidis increased in patients with active sarcoidosis. amplified il-17a expression in granulomas and the presence of il-17a + , il-17a + il-4 + and il-17a + ifn-γ + memory t helper cells in the circulation and bal indicate th17 cell involvement in granuloma induction and/or maintenance in sarcoidosis. sarcoidosis should therefore be considered as a th1/th17 multisystem disorder and anti-il-17/th17 approaches that control and reduce il-17amay be an option, therefore, for the treatment of sarcoidosis.here we provide a short overview as to the role of th17 cells as critical cells in the pathogenesis of sarcoidosis.
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Journal title:
iranian journal of allergy, asthma and immunologyجلد ۱۵، شماره ۴، صفحات ۳۳۴-۳۳۹
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